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That essential factor contributes to cerebral biochemical impairment (unrestricted production of ROS, elevated levels of RNS, altered levels of antioxidant glutathione, and reduced production and performance of major antioxidant molecules, thus leading to cellular damage, early instated senescence, and also neurodegeneration)
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In MPTP mice, neurodegeneration was shown to correlate with NADPH oxidase upregulation (242)
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